Baclofen Uses
Historically generic baclofen was created to be a drug for epilepsy in the 1920s. The effect on epilepsy was disappointing but it was found that in certain patients spasticity decreased. generic baclofen was and is still given orally with variable effects. In severely affected children, the oral dose is so high that side effects appear and generic baclofen loses its benefit. How and when baclofen came to be used in the spinal sac is not really clear but this is now an established method for the treatment of spasticity in many conditions.
baclofen is a white mostly odorless crystalline powder, with a molecular weight of 213.66 g/mol. It is insoluble in chloroform.
this drug is rapidly absorbed after oral administration and is widely distributed throughout the body.
generic baclofen can be administered either orally or intrathecally. Intrathecal administration is often preferred in spasticity patients, as very little of the oral dose actually reaches the spinal fluid. Intrathecal administration is particularly used in patients with multiple sclerosis who have severe painful spasms which are not controllable by oral this drug, or patients with spastic diplegia in whom management of spasticity is made easier by regular self-administering of this drug through its pump.
Glen Berry